Soybean Extract Rich in Lunasin Enhances p21 Expression in DMBA-Induced Breast Cancer in Rats: A Potential Adjuvant Therapy

Archives of Breast Cancer

Laurensia Evitaa, Kusmardi Kusmardi*b,c,d, Numlil Khaira Rusdie

Background: Breast cancer treatment in Indonesia faces challenges due to side effects, limited accessibility, and resistance to therapies like tamoxifen, highlighting the need for effective adjuvant strategies. Lunasin, a soybean-derived peptide, exh...

Ficus deltoidea Ethanol Extract Cytotoxic Activity on MCF-7 Treated Doxorubicin: An In Silico and In vitro Approach

Tropical Journal of Natural Product Research

Rizky C Putri, Kusmardi *, Rani W Hakim, Aditya E Nurfitrah

Female breast cancer is the most frequently diagnosed cancer worldwide, and the number of caseswill increase in the next 20 years. Doxorubicin is an effective first-line chemotherapy for breastcancer. Unfortunately, continuous administration of doxor...

Oxidative Stress, DNA Fragmentation and Caspase-3 Regulation in HIV-1 Positive Men: A Study of Sperm Preparation

International Journal of Technology

Margaretha Napitupulu, Friska Zai, Silvia W Lestari , Latisha Witjaksono, Zulfikar Drakel, Dhriti Bhavnani, Evy Yunihastuti, Gita Pratama, Ria Kodariah , Kusmardi Kusmardi

The impact of human immunodeficiency virus (HIV) infection on male fertility, specifically sperm quality, remains inconclusive in global studies. However, stable HIV-positive men undergoing antiretroviral therapy (ARV) experience improved quality of ...

Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches

Frontiers in Pharmacology Sec. Experimental Pharmacology and Drug Discovery

Fachrur Rizal Mahendra, Indira Prakoso, Alfa Marzelino, Muhamad Rizqy Fadhillah, Muhamad Rizqy Fadhillah, Syukriyansyah, M Muhammad Marsha, Azzami Hasibuan, Juniza Firdha Suparningtyas, Mikael Kristiadi, Aprijal Ghiyas Setiawan, Faris Izzatur Rahman, Anissa Nofita Sari , Nauval Rajwaa Raysendria, Ilham Kurniawan, Wawaimuli Arozal, Kusmardi Kusmardi

6-Gingerol Protects Against Hypertrophic Cardiomyopathy in High-Fat Diet/Low-Dose Streptozotocin-Induced Diabetic Rats

Research Journal of Pharmacognosy

Vivian Soetikno, Andika Yusuf Ramadhan, Savira Wijaya, Diski Saisa, Syifa Nurfitriyanti , Bryantlewi Santoso, Kusmardi Kusmardi, Shirly Gunawan, Somasundaram Arumugam, Remya Sreedhar

Background and objectives: Diabetes mellitus (DM)-induced hypertrophic cardiomyopathy (HCM) is the main reason for the high morbidity rate. 6-Gingerol has been shown to alleviate HCM by reducing oxidative stress and inflammation. The present study in...

Structure elucidation of active compounds from Coffea canephora Pierre ex A Froehner cascara and their potential as anticancer against breast cancer cells

Journal of Pharmacy & Pharmacognosy Research, 12 (1), 73-90

Novi Fajar Utami1,2, Berna Elya1*, Hayun1, Kusmardi Kusmardi3,4,5 1

Standardization of Phomopsis sp. extract and prediction of anti breast cancer activity from the main compound through molecular docking

IOP Conf. Ser.: Earth Environ. Sci. 1359 012138

H Husnawati1,2, K Kusmardi1,3, D Andrianto2, H Julistiono4, M Mulyadi4, N Setianingrum4, I M Artika2, and A E Z Hasan2

Endophytic fungi isolated from Indonesian soursop (Annona muricata) leaves, which have the potential to treat breast cancer, have been successfully isolated since 2016. Identification based on the Internal Transcribed Spacer (ITS) gene revealed that ...

Effect of Seahorse (Hippocampus comes L.) Extract on Population and Apoptotic of Spermatogenic and Leydig Cells in Rats After Depot Medroxyprogesterone Acetate Induction

Trop J Nat Prod Res, February 2024; 8(2):6272-6278

Retnaningtyas S. Dianty1, Yurnadi H. Midoen2*, Silvia W. Lestari2, Trisnawati Mundijo3-4, Kusmardi Kusmardi5-7

The Seahorse Hippocampus comes L. (HC) has been used in traditional medicine and haspharmacological activities known as a powerful aphrodisiac. Depot medroxyprogesterone acetate(DMPA) is a contraceptive drug that can reduce testosterone levels, as ha...

Inhibitory Mechanisms of Soybean Extract on the Development of Breast Cancer Through Modulation of Cellular Immune Response

Pharmacognosy Journal, 2024, 16, 1: 1-8

Andi Muh. Maulana1,2, Kusmardi Kusmardi1,3,4,5,*, Erni Hernawati Purwaningsih1,4,6, Andon Hestiantoro1,7, Taifo Mahmud8, Heri Wibowo9, Bambang Pontjo Priosoeryanto10, Primariadewi Rustamadji3, Numlil Khaira Rusdi11

Background: Breast cancer is the most frequently diagnosed cancer in women worldwide. Consumptionof soy products has been reported to reduce the incidence of and mortality rate for some cancers, includingbreast cancer. However, there are limited in v...

SCOV-CNN: A Simple CNN Architecture for COVID-19 Identification Based on the CT Images

JOIV : Int. J. Inform. Visualization, 8(1) - March 2024 175-182

Toto Haryanto a,*, Heru Suhartanto b, Aniati Murni b, Kusmardi c,d, Marina Yusoff e,f, Jasni Mohammad Zain e,f

Since the coronavirus was first discovered in Wuhan, it has widely spread and was finally declared a global pandemic by the WHO. Image processing plays an essential role in examining the lungs of affected patients. Computed Tomography (CT) and X-ray ...